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| Colombo,Arnaldo Lopes; Guimarães,Thaís; Camargo,Luis Fernando Aranha; Richtmann,Rosana; Queiroz-Telles,Flavio de; Salles,Mauro José Costa; Cunha,Clóvis Arns da; Yasuda,Maria Aparecida Shikanai; Moretti,Maria Luiza; Nucci,Marcio. |
| Candida infections account for 80% of all fungal infections in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream infections are now a major challenge for tertiary hospitals worldwide due to their high prevalence and mortality rates. The incidence of candidemia in tertiary public hospitals in Brazil is approximately 2.5 cases per 1000 hospital admissions. Due to the importance of this infection, the authors provide a review of the diversity of the genus Candida and its clinical relevance, the therapeutic options and discuss the treatment of major infections caused by Candida. Each topography is discussed with regard to epidemiological, clinical and laboratory diagnostic and therapeutic recommendations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candidiasis; Candidemia; Treatment; Antifungals. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300001 |
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| Nucci,Marcio; Colombo,Arnaldo L.. |
| Problems with resistance to antifungal drugs have emerged due to an increase in the incidence of systemic fungal infections and widespread use of antifungal agents. Accordingly, efforts have been made to develop adequate fungal susceptibility tests. The ideal test should have high intra and inter-laboratory reproducibility, good correlation with the clinical outcome, and should be easy to perform. While no such test has yet been developed, advances have been made. Over the past decade, many reports of fungal resistance have been published, most of them in AIDS patients. Though the frequency of resistant strains is still low in neutropenic cancer patients, and is mostly limited to Candida glabrata and Candida krusei, resistance to Candida albicans has also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Resistance; Neutropenic. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300004 |
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| Nucci,Marcio; Braga,Paula Rocha; Nouér,Simone A.; Anaissie,Elias. |
| ABSTRACT Background: The impact of central venous catheter (CVC) removal on the outcome of patients with candidemia is controversial, with studies reporting discrepant results depending on the time of CVC removal (early or any time during the course of candidemia). Objective: Evaluate the effect of time to CVC removal, early (within 48 h from the diagnosis of candidemia) vs. removal at any time during the course of candidemia, on the 30-day mortality. Methods: Retrospective cohort study of 285 patients with candidemia analyzing CVC removal within 48 h (first analysis) or at any time (second analysis). Results: A CVC was in place in 212 patients and was removed in 148 (69.8%), either early (88 patients, 41.5%) or late (60 patients, 28.3%). Overall, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candidemia; Central venous catheter; Mortality; Multivariate analysis; Candida. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600455 |
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